73776-19-9

Usage

InChI:InChI=1/C11H9NO4/c1-16-11(15)8-9(13)6-4-2-3-5-7(6)12-10(8)14/h2-5,15H,1H3,(H,12,14)

Upstream product

• 206363-41-9 N-methoxycarbonylacetyl-anthranilic acid methyl ester 
• 118-48-9 isatoic anhydride 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 67-56-1 methanol 
• 169216-68-6 2-chloro-4-hydroxyquinoline-3-carboxylic acid 
• 40059-53-8 ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 108-59-8 malonic acid dimethyl ester 
• 118-92-3 anthranilic acid 
• 159657-34-8 ethyl 2-(o-methoxycarbonylphenyl)carbamoylacetate 
• 89-52-1 o-acetylamino-benzoic acid 
• 134-20-3 2-carbomethoxyaniline 
• 41470-88-6 2-ethoxy-4H-benzo[d][1,3]oxazin-4-one 
• 6315-94-2 ethyl 2,4-dichloroquinoline-3-carboxylate 

Downstream Products

• 213181-19-2 2-Oxo-4-(toluene-4-sulfonyloxy)-1,2-dihydro-quinoline-3-carboxylic acid methyl ester 
• 128366-07-4 4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid cyclohexylamide 
• 70254-43-2 4-Hydroxy-2-quinolone 
• 213181-22-7 1H-4-chloro-2-oxoquinoline-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

SUBSTITUTED 2, 4-DIAMINO-QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein which exhibit strong inhibition effects on various cancer cell lines. The compounds disclosed herein are useful for the treatment of proliferative diseases, including neoplastic diseases such as cancer and non- neoplastic disorders such as rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient and optionally one or more additional therapeutically active agents, including anticancer agents. This application also discloses methods for treating a proliferative disease, including neoplastic diseases such as cancer and non- neoplastic disorders such as rheumatoid arthritis.

Structure of the imine 4-hydroxy-2-quinoline ketone compound, and its preparation and use

The invention relates to 4-hydroxy-2-quinolinone compounds containing an imine structure, and preparation and an application thereof. A general formula is represented as the formula (I), wherein meanings of groups in the formula are defined in the specification. The compounds represented by the general formula (I) have quite good herbicidal and fungicidal activities and are widely applied in prevention and treatment of weeds and pathogenic bacteria of crops.

Reactivity of 2-methyl-4H-3,1-benzoxazin-4-ones and 2-methyl-4H-pyrido[2,3- d][1,3]oxazin-4-one under microwave irradiation conditions

The reactivity of variably substituted 2-methyl-4H-3,1-benzoxazin-4-ones and 2-methyl-4H-pyrido[2,3-d][1,3]oxazin-4-one towards carbon and oxygen nucleophiles under microwave irradiation conditions was investigated. Optimization of the reaction conditions of oxazinones with carbon nucleophiles led to the synthesis of a series of 4-hydroxy-quinolin-2-ones and 4-hydroxy-1,8-naphthyridin-2-ones in high yields, whereas reaction with a variety of alcohols proceeded smoothly to the formation of the corresponding N-acetyl-anthranilates and nicotinates.

INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE

The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these comp

MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Alkylidenephosphoranes in heterocyclic synthesis: Reactivity of benzoxazinones with resonance-stabilized phosphorus ylides

2H-3,1-Benzoxazine-2,4(1H)-dione and its N-methyl analogue react with alkylidenephosphoranes to give substituted quinolines and benzazepines as well as indanone and furan derivatives. Reaction mechanisms to explain the formation of products obtained are outlined. Georg Thieme Verlag Stuttgart.

4-Hydroxyquinol-2-ones. 85*. Synthesis of 2-chloro-4- hydroxyquinoline-3-carboxylic acid ethyl ester

The behavior of 2-chloro-4-hydroxy- and 4-chloro-2-oxoquinoline-3- carboxylic acids under acid catalyzed esterification conditions with methanol has been studied. A method is proposed for obtaining 2-chloro-4- hydroxyquinoline-3-carboxylic acid ethyl ester.

Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1

We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.

Synthesis of 3-substituted 4-hydroxyquinolin-2-ones via C-acylation reactions of active methylene compounds with functionalized 3,1-benzoxazin-4- ones

A general protocol for the construction of 4-hydroxyquinolin-2-ones is described. Benzoxazinones react with the anion of active methylene compounds to produce the functionalized C-acylation compounds in very good yields. These key intermediates are cyclized to the desired quinolinones (25-40) under basic conditions. Spectral data and physical characteristics for all compounds are reported.

Solution-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones

Ion-exchange resins catalyse an intramolecular Claisen-type condensation leading to the title compounds, and also serve to purify the products.