3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile

Base Information

Chemical Name:3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile
CAS No.:86289-03-4
Molecular Formula:C₁₄H₉ClN₂O₂
Molecular Weight:272.691
Hs Code.:

Synonyms:3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile

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Chemical Property of 3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile

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Technology Process of 3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile

There total 1 articles about 3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 2788-86-5
4-Chlorostyrene oxide

: 937-18-8
methyl 4-cyanopyrrole-2-carboxylate

: 86289-03-4
3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 100 ℃; for 18h;
DOI:10.1021/jo00167a016

Reference yield: 79.0%

: 86289-03-4
3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile

: 86288-97-3
1-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-cyano-1H-pyrrole-2-carboxylic acid

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; for 0.25h; Ambient temperature;
DOI:10.1021/jo00167a016

Reference yield:

: 86289-03-4
3-(4-Chloro-phenyl)-1-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-7-carbonitrile

: 86307-70-2
1-[(Z)-2-(4-Chloro-phenyl)-vinyl]-4-cyano-1H-pyrrole-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / potassium tert-butoxide / dimethylformamide / 0.25 h / Ambient temperature

2: 86 percent / aq. ethanol / 5 h / Irradiation

3: dichloromethyl methyl ether / CH₂Cl₂ / Heating

With Dichloromethyl methyl ether; potassium tert-butylate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00167a016