Benzyl-PEG5-Azide

Base Information

• Chemical Name: Benzyl-PEG5-Azide
• CAS No.: 86770-72-1
• Molecular Formula: C₁₇H₂₇N₃O₅
• Molecular Weight: 353.418
• Mol file: 86770-72-1.mol

Synonyms:[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxymethyl]-benzene

Chemical Property of Benzyl-PEG5-Azide

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98.5% ^*data from raw suppliers

Bromoacetamido-PEG2-azide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bromoacetamido-PEG2-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide.The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.

Technology Process of Benzyl-PEG5-Azide

There total 6 articles about Benzyl-PEG5-Azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

[2-(2-{2-[2-(2-Chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxymethyl]-benzene (105891-52-9) → [2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxymethyl]-benzene (86770-72-1)

Guidance literature:

With sodium azide;

Reference yield:

2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol (57671-28-0,1201808-31-2) → [2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxymethyl]-benzene (86770-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / SOCl₂ / 18 h / 80 °C

2: 96 percent / NaN₃

With thionyl chloride; sodium azide;

Reference yield:

1-phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl 4-methylbenzene-1-sulfonate (129086-10-8) → [2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxymethyl]-benzene (86770-72-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 50 ℃; for 12h;

DOI:10.1021/ja00091a005

upstream raw materials:

1-phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl 4-methylbenzene-1-sulfonate

[2-(2-{2-[2-(2-Chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxymethyl]-benzene

Pentaethylene glycol

2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol

Downstream raw materials:

2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol

2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethylamine