ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

Base Information

Chemical Name:ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate
CAS No.:1265323-48-5
Molecular Formula:C₁₇H₂₂N₂O₃
Molecular Weight:302.373
Hs Code.:

Synonyms:ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

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Technology Process of ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

There total 12 articles about ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 179694-33-8
(S)-(+)-2-(4-cyanophenyl)oxirane

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1265323-48-5
ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

Guidance literature:: With dmap; In isopropyl alcohol; at 50 ℃; stereospecific reaction; Inert atmosphere;
DOI:10.1021/acs.oprd.6b00366

Reference yield:

: 1265323-53-2
ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide

: 1265323-48-5
ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

Guidance literature:: With D-glucose; DL-dithiothreitol; β-nicotinamide adenine dinucleotide sodium salt; magnesium sulfate; sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 4.5h; pH=6.5 - 7; Phosphate buffer;