ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide

Base Information

• Chemical Name: ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide
• CAS No.: 1265323-53-2
• Molecular Formula: BrH*C₁₇H₂₀N₂O₃
• Molecular Weight: 381.269
• Mol file: 1265323-53-2.mol

Synonyms:ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide

Chemical Property of ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide

There total 1 articles about ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-Cyanophenacyl bromide (20099-89-2) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide (1265323-53-2)

Guidance literature:

In toluene; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00373

Reference yield:

ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide (1265323-53-2) → ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate (1265323-48-5)

Guidance literature:

With D-glucose; DL-dithiothreitol; β-nicotinamide adenine dinucleotide sodium salt; magnesium sulfate; sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 4.5h; pH=6.5 - 7; Phosphate buffer;

Reference yield:

ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide (1265323-53-2) + methylmagnesium bromide (75-16-1) → C18H24N2O3

Guidance literature:

ethyl (3S)-1-[2-(4-cyanophenyl)-2-oxoethyl]piperidine-3-carboxylate hydrobromide; methylmagnesium bromide; In tetrahydrofuran; for 1h;

With water; In tetrahydrofuran;

upstream raw materials:

4-Cyanophenacyl bromide

(S)-(+)-nipecotic acid ethyl ester

Downstream raw materials:

ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

ethyl (3S)-1-((2S)-2-hydroxy-2-(4-((Z)-N'-hydroxycarbamimidoyl)-phenyl)ethyl)piperidine-3-carboxylate

ethyl (3S)-1-[(2S)-2-hydroxy-2-(4-{5-[3-phenyl-4-(trifluoromethyl)isoxazol-5-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethyl]piperidine-3-carboxylate

(S)-ethyl 1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-cyanophenyl)ethyl)piperidine-3-carboxylate