2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester

Base Information

Chemical Name:2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester
CAS No.:308846-84-6
Molecular Formula:C₁₁H₁₀BrNO₃
Molecular Weight:284.109
Hs Code.:

Synonyms:2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester

Suppliers and Price of 2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester

There total 3 articles about 2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 716369-03-8
(2S)-(2-bromo-benzoylamino)-3-hydroxy-propionic acid methyl ester

: 308846-84-6
2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester

Guidance literature:: (2S)-(2-bromo-benzoylamino)-3-hydroxy-propionic acid methyl ester; With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 1h;

With potassium carbonate; In dichloromethane; at -78 ℃; for 3h;
DOI:10.1002/jccs.200500115

Reference yield:

: 7154-66-7
2-bromobenzoic acid chloride

: 308846-84-6
2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / Et₃N / CH₂Cl₂ / 4 h / 25 °C

2.1: diethylaminosulfurtrifluoride / CH₂Cl₂ / 1 h / -78 °C

2.2: 99 percent / K₂CO₃ / CH₂Cl₂ / 3 h / -78 °C

With diethylamino-sulfur trifluoride; triethylamine; In dichloromethane;
DOI:10.1002/jccs.200500115

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 308846-84-6
2-(2-bromo-phenyl)-4,5-dihydro-oxazole-(4S)-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: SOCl₂ / 3 h / 25 °C

2.1: 85 percent / Et₃N / CH₂Cl₂ / 4 h / 25 °C

3.1: diethylaminosulfurtrifluoride / CH₂Cl₂ / 1 h / -78 °C

3.2: 99 percent / K₂CO₃ / CH₂Cl₂ / 3 h / -78 °C

With thionyl chloride; diethylamino-sulfur trifluoride; triethylamine; In dichloromethane;
DOI:10.1002/jccs.200500115