N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
CAS No.:1221713-71-8
Molecular Formula:C₃₁H₂₄FN₅O₃
Molecular Weight:533.562
Hs Code.:

Synonyms:N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Chemical Property of N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Technology Process of N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

There total 10 articles about N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1221713-69-4
N-(4-(5-bromopyrrolo[1,2-b]pyridazin-4-yloxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

: 98-80-6
phenylboronic acid

: 1221713-71-8
N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 2h;

Reference yield:

: 156335-37-4
ethyl 1,4-dihydro-4-oxopyrrolo<1,2-b>pyridazine-3-carboxylate

: 1221713-71-8
N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; water / ethanol / 100 °C

1.2: pH 2

2.1: dimethyl sulfoxide / 1 h / 150 °C

3.1: toluene / 1 h / Reflux; Inert atmosphere

4.1: water; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 80 °C

5.1: N-Bromosuccinimide / chloroform / 0 °C

6.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 1.5 h / 70 °C

7.1: triethylamine; HATU / N,N-dimethyl-formamide / 50 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

With N-Bromosuccinimide; water; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; HATU; sodium hydroxide; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 888720-26-1
pyrrolo[1,2-b]pyridazin-4(1H)-one

: 1221713-71-8
N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 1 h / Reflux; Inert atmosphere

2: water; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 80 °C

3: N-Bromosuccinimide / chloroform / 0 °C

4: zinc; ammonium chloride / tetrahydrofuran; methanol / 1.5 h / 70 °C

5: triethylamine; HATU / N,N-dimethyl-formamide / 50 °C

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

With N-Bromosuccinimide; water; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; HATU; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;