N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
CAS No.:1558030-40-2
Molecular Formula:C₂₇H₂₄FN₅O₄
Molecular Weight:501.517
Hs Code.:

Synonyms:N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Chemical Property of N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Technology Process of N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

There total 8 articles about N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.2%

: 1552280-62-2
N-(4-((2-aminopyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1558030-40-2
N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 403-19-0
2-fluoro-4-nitrophenol

: 1558030-40-2
N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 45 °C

3: sodium hydride / dimethyl sulfoxide; mineral oil / 20 h / 160 °C

4: [bis(acetoxy)iodo]benzene / water; ethyl acetate; acetonitrile / 8.5 h / 0 - 20 °C

5: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile; mineral oil;

Reference yield:

: 99586-65-9
4-chloropicolinamide

: 1558030-40-2
N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / dimethyl sulfoxide; mineral oil / 20 h / 160 °C

2: [bis(acetoxy)iodo]benzene / water; ethyl acetate; acetonitrile / 8.5 h / 0 - 20 °C

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With [bis(acetoxy)iodo]benzene; sodium hydride; triethylamine; In dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile; mineral oil;