N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N⁽⁶⁾-benzoyladenin-9-yl)-(2'R)-proline

Base Information

• Chemical Name: N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N⁽⁶⁾-benzoyladenin-9-yl)-(2'R)-proline
• CAS No.: 1286700-62-6
• Molecular Formula: C₃₄H₃₁N₇O₅
• Molecular Weight: 617.664

Synonyms:N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N⁽⁶⁾-benzoyladenin-9-yl)-(2'R)-proline

Chemical Property of N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N⁽⁶⁾-benzoyladenin-9-yl)-(2'R)-proline

Chemical Property:

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Technology Process of N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N⁽⁶⁾-benzoyladenin-9-yl)-(2'R)-proline

There total 5 articles about N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N⁽⁶⁾-benzoyladenin-9-yl)-(2'R)-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N(6)-benzoyladenin-9-yl)-(2'R)-proline diphenylmethyl ester (1286700-51-3) → N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N(6)-benzoyladenin-9-yl)-(2'R)-proline (1286700-62-6)

Guidance literature:

With trifluoroacetic acid; In methoxybenzene; at 30 ℃;

DOI:10.1080/15257770.2010.547839

Reference yield:

(2R,4R)-4-(6-Benzoylamino-purin-9-yl)-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester (189163-56-2) → N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N(6)-benzoyladenin-9-yl)-(2'R)-proline (1286700-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 20 °C

2: sodium acetate; sodium cyanoborohydride / methanol / 1 h / 30 °C

3: trifluoroacetic acid / methoxybenzene / 30 °C

With sodium acetate; sodium cyanoborohydride; trifluoroacetic acid; In methanol; methoxybenzene; acetonitrile;

DOI:10.1080/15257770.2010.547839

Reference yield:

(+/-)-N-fluorenylmethoxycarbonyl-3-amino-1,2-propanediol (167700-44-9) → N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N(6)-benzoyladenin-9-yl)-(2'R)-proline (1286700-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium periodate / water; acetonitrile / 3 h / 30 °C

2: sodium acetate; sodium cyanoborohydride / methanol / 1 h / 30 °C

3: trifluoroacetic acid / methoxybenzene / 30 °C

With sodium periodate; sodium acetate; sodium cyanoborohydride; trifluoroacetic acid; In methanol; water; methoxybenzene; acetonitrile;

DOI:10.1080/15257770.2010.547839

upstream raw materials:

(9H-fluoren-9-yl)methyl(2-oxoethyl)carbamate

N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-4'-(N⁽⁶⁾-benzoyladenin-9-yl)-(2'R)-proline diphenylmethyl ester

(fluorenylmethoxy)carbonyl chloride

(+/-)-N-fluorenylmethoxycarbonyl-3-amino-1,2-propanediol

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