(9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate

Base Information

• Chemical Name: (9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate
• CAS No.: 156939-62-7
• Molecular Formula: C17H15 N O3
• Molecular Weight: 281.311
• Hs Code.: 2924299090
• European Community (EC) Number: 865-681-6
• DSSTox Substance ID: DTXSID801347615
• Nikkaji Number: J1.225.263C
• Mol file: 156939-62-7.mol

Synonyms:(9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate;156939-62-7;Fmoc-Gly-Wang resin;(9H-Fluoren-9-yl)methyl (2-oxoethyl)carbamate;9H-fluoren-9-ylmethyl N-(2-oxoethyl)carbamate;MFCD11519176;MFCD00801253;Fmoc-2-aminoacetaldehyde;N-Fmoc glycinal;Fmoc-Gly Wang resin;(Fmoc-Amino)acetaldehyde;N-fmoc-2-aminoacetaldehyde;SCHEMBL1888475;DBTMQODRSDEGRZ-UHFFFAOYSA-N;DTXSID801347615;AMY21368;AKOS015909427;CS-W018797;DS-13459;9H-Fluoren-9-ylmethyl (2-oxoethyl)carbamate;FT-0604021;A18246;Fmoc-Gly-Wang resin 100-200 mesh, 1% DVB;M03477;O10147;EN300-7363653;Fmoc-Gly-Wang Resin (80-160 ?m, 1% DVB);Fmoc-Gly-Wang Resin (200-400 mesh, 1% DVB);(9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate, 95%;(9H-FLUOREN-9-YL)METHYL N-(2-OXOETHYL)CARBAMATE;Z1741981216;Fmoc-Gly-Wang TentaGel S (90 ?m, 0.2-0.22 mmol/g);Carbamic acid, N-(2-oxoethyl)-, 9H-fluoren-9-ylmethyl ester;Fmoc-Gly-4-methoxybenzhydryl resin (100-200 mesh, > 0.4 mmol/g);Fmoc-Gly-Wang resin, extent of labeling: 0.4-0.8 mmol/g loading

Chemical Property of (9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 141.0-143.0℃
• Refractive Index: 1.598
• Boiling Point: 477.458°C at 760 mmHg
• PKA: 10.72±0.46(Predicted)
• Flash Point: 242.558°C
• PSA: 55.40000
• Density: 1.231g/cm³
• LogP: 3.11490
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 281.10519334
• Heavy Atom Count: 21
• Complexity: 362

Purity/Quality:

97% ^*data from raw suppliers

(9H-Fluoren-9-yl)methyl2-oxoethylcarbamate 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCC=O

Technology Process of (9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate

There total 12 articles about (9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(9-fluorenylmethoxycarbonyl)-2-aminoethanol (105496-31-9) → (9H-fluoren-9-yl)methyl(2-oxoethyl)carbamate (156939-62-7)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; at 80 ℃;

DOI:10.1021/ol026427n

Reference yield: 99.0%

(+/-)-N-fluorenylmethoxycarbonyl-3-amino-1,2-propanediol (167700-44-9) → (9H-fluoren-9-yl)methyl(2-oxoethyl)carbamate (156939-62-7)

Guidance literature:

With potassium metaperiodate; In water; acetone;

DOI:10.1016/j.tetlet.2008.05.114

Reference yield: 89.0%

(9H-fluoren-9-yl)methyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate (156939-65-0) → (9H-fluoren-9-yl)methyl(2-oxoethyl)carbamate (156939-62-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

DOI:10.1021/ol0275567

upstream raw materials:

9H-fluoren-9-ylmethyl (2-chloro-2-oxoethyl)carbamate

(9H-fluoren-9-yl)methyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate

(fluorenylmethoxy)carbonyl chloride

ethanolamine

Downstream raw materials:

C₄₅⁽¹³⁾C₂H₅₄N₆O₉

Fmoc-Gly-α[CH2NH]-Ile-O-Bzl

[6-((4S)-4-benzyl-2-oxo-oxazolidin-3-yl)-(2S,3S,5S)-2-hydroxy-3,5-dimethyl-4,6-dioxohexyl]-carbamic acid 9H-fluoren-9-ylmethyl ester