4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester

Base Information

Chemical Name:4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester
CAS No.:1380646-59-2
Molecular Formula:C₂₂H₂₅FO₄
Molecular Weight:372.437
Hs Code.:

Synonyms:4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester

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Chemical Property of 4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester

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Technology Process of 4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester

There total 2 articles about 4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 459-46-1
4-Fluorobenzyl bromide

: ethyl 4-(2-tert-butoxy-2-oxo-ethyl)benzoate

: 1380646-59-2
4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester

Guidance literature:: ethyl 4-(2-tert-butoxy-2-oxo-ethyl)benzoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.666667h;

4-Fluorobenzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

Reference yield:

: 321745-86-2
2-tert-butoxy-2-oxoethylzinc chloride

: 1380646-59-2
4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / diethyl ether; tetrahydrofuran / 0.1 h / 120 °C / Inert atmosphere; Microwave reactor; Sealed vial

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C

2.2: 1 h / 20 °C

With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;