4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide

Base Information

Chemical Name:4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide
CAS No.:1380646-09-2
Molecular Formula:C₂₅H₂₂FN₃O₄
Molecular Weight:447.466
Hs Code.:

Synonyms:4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide

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Chemical Property of 4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide

Chemical Property:

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Technology Process of 4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide

There total 5 articles about 4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1380646-61-6
4-[1-(benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-benzoic acid

: 141-43-5
ethanolamine

: 1380646-09-2
4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1380646-06-9
4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester

: 1380646-09-2
4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water / ethanol / 4 h / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1380646-59-2
4-[1-tert-butoxycarbonyl-2-(4-fluoro-phenyl)-ethyl]-benzoic acid ethyl ester

: 1380646-09-2
4-[1-(Benzooxazol-2-ylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-N-(2-hydroxy-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: potassium hydroxide; water / ethanol / 4 h / 20 °C

4: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With dmap; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;