N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide

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Chemical Name:N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide
CAS No.:1609257-18-2
Molecular Formula:C₃₃H₄₀N₆O₄
Molecular Weight:584.718
Hs Code.:

Synonyms:N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide

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Chemical Property of N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide

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Technology Process of N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide

There total 3 articles about N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 79-03-8
propionyl chloride

: 611168-76-4
1-(1-(3-aminophenyl)-3-(tert-butyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea

: 1609257-18-2
N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide

Guidance literature:: 1-(1-(3-aminophenyl)-3-(tert-butyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

propionyl chloride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm500167q

Reference yield:

: 317806-89-6,285984-50-1
C₁₆H₂₀N₂O₂*ClH

: 1609257-18-2
N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 9 h / 60 °C

2.1: 5%-palladium/activated carbon; ammonium formate / ethanol / 1.5 h / 90 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 0 °C

3.2: 2 h / 20 °C

With 5%-palladium/activated carbon; ammonium formate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm500167q

Reference yield:

: 1012883-12-3
C₁₆H₁₇Cl₃N₄O₄

: 1609257-18-2
N-(3-(3-(tert-butyl)-5-(3-(4-(2-morpholinoethoxy)naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)phenyl)propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 9 h / 60 °C

2.1: 5%-palladium/activated carbon; ammonium formate / ethanol / 1.5 h / 90 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 0 °C

3.2: 2 h / 20 °C

With 5%-palladium/activated carbon; ammonium formate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm500167q