Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate

Base Information

Chemical Name:Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate
CAS No.:1236409-79-2
Molecular Formula:C₁₈H₁₈N₂O₄
Molecular Weight:326.352
Hs Code.:

Synonyms:Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate

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Chemical Property of Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate

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Technology Process of Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate

There total 1 articles about Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1236409-78-1
methyl 1-(4-(2-cyano-N-(3-ethoxy-3-oxopropyl)acetamido)phenyl)cyclobutanecarboxylate

: 1236409-79-2
Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate

Guidance literature:: methyl 1-(4-(2-cyano-N-(3-ethoxy-3-oxopropyl)acetamido)phenyl)cyclobutanecarboxylate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at 20 ℃;

With hydrogenchloride; water;

Reference yield: 84.0%

: 67-56-1
methanol

: 1236409-79-2
Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate

: 1236409-80-5
methyl 1-(4-(3-cyano-4-methoxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate

Guidance literature:: Methyl 1-(4-(3-cyano-4-hydroxy-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)cyclobutanecarboxylate; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h;

methanol; In dichloromethane; Reflux;