((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate

Base Information

Chemical Name:((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate
CAS No.:885621-72-7
Molecular Formula:C₁₄H₁₃F₃O₅
Molecular Weight:318.249
Hs Code.:

Synonyms:((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate

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Technology Process of ((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate

There total 3 articles about ((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 885621-68-1
((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

: 885621-72-7
((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In toluene; for 12h; Heating;
DOI:10.1021/jo052652h

Reference yield:

: 634181-84-3
1-O-acetyl-2-O-benzyl-5-O-benzoyl-3-deoxy-3,3-difluoro-α-D-arabinofuranose

: 885621-72-7
((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaBrO₃; Na₂S₂O₄ / ethyl acetate; H₂O / 5 h / 20 °C

2: 88 percent / bis(2-methoxyethyl)aminosulfur trifluoride / toluene / 12 h / Heating

With sodium bromate; sodium dithionite; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In water; ethyl acetate; toluene;
DOI:10.1021/jo052652h

Reference yield:

: ((2R,4R)-5-acetoxy-4-(benzyloxy)-3,3-difluorotetrahydrofuran-2-yl)methyl benzoate

: 885621-72-7
((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium bromate; sodium dithionite / ethyl acetate / 6 h / 25 °C

2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 16 h / 25 - 120 °C

With sodium bromate; sodium dithionite; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; ethyl acetate;