885621-68-1

Basic information

• Product Name: ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate
• Synonyms: ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate
• CAS NO: 885621-68-1
• Molecular Weight: 316.258
• Mol File: 885621-68-1.mol

Chemical Properties

• CAS DataBase Reference: ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate(885621-68-1)
• EPA Substance Registry System: ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate(885621-68-1)

Safety Data

• Hazardous Substances Data: 885621-68-1(Hazardous Substances Data)

Upstream product

• 634181-84-3 1-O-acetyl-2-O-benzyl-5-O-benzoyl-3-deoxy-3,3-difluoro-α-D-arabinofuranose 
• 634181-78-5 (R)-4-((R)-1-(benzyloxy)-2,2-difluorobut-3-en-1-yl)-2,2-dimethyl-1,3-dioxolane 
• 634181-79-6 (2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobutane-1,2-diol 
• 634181-81-0 (2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 885621-69-2 1-O-acetyl-2,5-di-O-benzoyl-3-deoxy-3,3-difluoro-D-arabinofuranose 
• 885621-70-5 N⁴-benzoyl-N¹-(2,5-di-O-benzoyl-3-deoxy-3,3-difluoro-α-D-arabinofuranosyl)cytosine 
• 885621-78-3 Benzoic acid (2R,4S,5R)-4-acetoxy-5-(6-chloro-purin-9-yl)-3,3-difluoro-tetrahydro-furan-2-ylmethyl ester 
• 885621-72-7 ((2R,4S,5S)-4-acetoxy-3,3,5-trifluorotetrahydrofuran-2-yl)methyl benzoate 

Relevant articles and documents

Synthesis of L- and D-β-3′-deoxy-3′,3′- difluoronucleosides

Both L- and D-β-3′-deoxy-3′,3′-difluoronucleosides were synthesized starting from the key intermediate difluorohomoallyl alcohol 11. Deoxo-Fluor was accidentally found to be efficient in reversing the hydroxyl configuration of 34, and the desired product

NOVEL STING AGONISTS

The present invention provides compounds of Formula I′: wherein , W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.