((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

Base Information

Chemical Name:((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate
CAS No.:885621-68-1
Molecular Formula:C₁₄H₁₄F₂O₆
Molecular Weight:316.258
Hs Code.:

Synonyms:((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

Suppliers and Price of ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

There total 9 articles about ((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 634181-84-3
1-O-acetyl-2-O-benzyl-5-O-benzoyl-3-deoxy-3,3-difluoro-α-D-arabinofuranose

: 885621-68-1
((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: With sodium bromate; sodium dithionite; In water; ethyl acetate; at 20 ℃; for 5h;
DOI:10.1021/jo052652h

Reference yield: 90.0%

: ((2R,4R)-5-acetoxy-4-(benzyloxy)-3,3-difluorotetrahydrofuran-2-yl)methyl benzoate

: 885621-68-1
((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: With sodium bromate; sodium dithionite; In ethyl acetate; at 25 ℃; for 6h;

Reference yield:

: (R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluorobut-3-en-1-ol

: 885621-68-1
((2R,4R,5R)-5-acetoxy-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutylammomium bromide; sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: potassium osmate(VI) dihydrate; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); potassium carbonate; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 24 h / 0 °C

3.1: pyridine / dichloromethane / 2 h / -70 °C

4.1: acetic acid / water / 1.5 h / 50 °C

5.1: sodium periodate / acetone / 1.5 h / 25 °C

6.1: dmap / dichloromethane / 16 h / 25 °C

7.1: sodium bromate; sodium dithionite / ethyl acetate / 6 h / 25 °C

With pyridine; dmap; potassium osmate(VI) dihydrate; sodium bromate; sodium periodate; sodium dithionite; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); tetrabutylammomium bromide; sodium hydride; potassium carbonate; acetic acid; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone; tert-butyl alcohol;