ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Base Information

Chemical Name:ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate
CAS No.:1331943-19-1
Molecular Formula:C₁₈H₁₁ClF₃NO₈S
Molecular Weight:493.801
Hs Code.:

Synonyms:ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Chemical Property:

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Technology Process of ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

There total 8 articles about ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1331943-18-0
ethyl 2-(4-chlorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

: 1331943-19-1
ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 2881-63-2
ethyl (4-chlorobenzoyl)acetate

: 1331943-19-1
ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / ethanol; tert-butyl methyl ether / 2 h / 75 - 95 °C / Inert atmosphere

2.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C

3.1: nitric acid / chloroform / 2.5 h / 0 °C / Cooling with ice

4.1: boron trichloride / dichloromethane / 0.33 h / Cooling with ice; Inert atmosphere

4.2: Cooling with ice

5.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With dmap; nitric acid; boron trichloride; caesium carbonate; triethylamine; zinc(II) chloride; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; tert-butyl methyl ether; chloroform;

Reference yield:

: 1192977-48-2
ethyl 2-(4-chlorophenyl)-5-hydroxybenzofuran-3-carboxylate

: 1331943-19-1
ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C

2.1: nitric acid / chloroform / 2.5 h / 0 °C / Cooling with ice

3.1: boron trichloride / dichloromethane / 0.33 h / Cooling with ice; Inert atmosphere

3.2: Cooling with ice

4.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With dmap; nitric acid; boron trichloride; caesium carbonate; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform;