2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole

Base Information

• Chemical Name: 2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole
• CAS No.: 1610037-88-1
• Molecular Formula: C₁₉H₁₂FN₃O₅S
• Molecular Weight: 413.386
• Mol file: 1610037-88-1.mol

Synonyms:2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole

Chemical Property of 2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole

There total 4 articles about 2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.01%

2-(4-fluorophenyl)benzo[d]oxazol-5-amine (116248-10-3) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → 2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole (1610037-88-1)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/cmdc.201400010

Reference yield:

4-Fluorobenzoic acid (456-22-4) → 2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole (1610037-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / 2 h / 200 °C

2: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; In dichloromethane;

DOI:10.1007/s00044-015-1499-1

Reference yield:

2,4-diaminophenol dihydrochloride (137-09-7) → 2-(4-fluorophenyl)-5-(4-nitrophenylsulfonamido)benzoxazole (1610037-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / 2 h / 200 °C

2: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; In dichloromethane;

DOI:10.1007/s00044-015-1499-1

upstream raw materials:

2-(4-fluorophenyl)benzo[d]oxazol-5-amine

4-Nitrobenzenesulfonyl chloride

4-Fluorobenzoic acid

2,4-diaminophenol dihydrochloride