(2S,3R)-N-[(2-chloro-6-methoxypyridin-3-yl)carbonyl]threonine benzyl ester

Base Information

Chemical Name:(2S,3R)-N-[(2-chloro-6-methoxypyridin-3-yl)carbonyl]threonine benzyl ester
CAS No.:1452389-65-9
Molecular Formula:C₁₈H₁₉ClN₂O₅
Molecular Weight:378.812
Hs Code.:

Synonyms:(2S,3R)-N-[(2-chloro-6-methoxypyridin-3-yl)carbonyl]threonine benzyl ester

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Chemical Property of (2S,3R)-N-[(2-chloro-6-methoxypyridin-3-yl)carbonyl]threonine benzyl ester

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Technology Process of (2S,3R)-N-[(2-chloro-6-methoxypyridin-3-yl)carbonyl]threonine benzyl ester

There total 2 articles about (2S,3R)-N-[(2-chloro-6-methoxypyridin-3-yl)carbonyl]threonine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 201274-07-9
L-threonine benzyl ester oxalate salt

: 503000-87-1
2-chloro-6-methoxypyridine-3-carboxylic acid

: 1452389-65-9
(2S,3R)-N-[(2-chloro-6-methoxypyridin-3-yl)carbonyl]threonine benzyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1002/anie.201302372

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1452389-65-9
(2S,3R)-N-[(2-chloro-6-methoxypyridin-3-yl)carbonyl]threonine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 3 h / 0 °C

With potassium tert-butylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1002/anie.201302372