2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

Base Information

Chemical Name:2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine
CAS No.:1452389-56-8
Molecular Formula:C₁₈H₁₅ClN₂O₄
Molecular Weight:358.781
Hs Code.:

Synonyms:2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

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Chemical Property of 2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

Chemical Property:

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Technology Process of 2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

There total 5 articles about 2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1452389-66-0
benzyl (S)-2-(2-chloro-6-methoxynicotamido)-3-oxobutanoate

: 1452389-56-8
2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

Guidance literature:: With iodine; triethylamine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 15h;
DOI:10.1002/anie.201302372

Reference yield:

: 503000-87-1
2-chloro-6-methoxypyridine-3-carboxylic acid

: 1452389-56-8
2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 3 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 6 h / 20 °C / Inert atmosphere

3: triethylamine; triphenylphosphine; iodine / dichloromethane / 15 h / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iodine; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: |Dess-Martin Oxidation;
DOI:10.1002/anie.201302372

Reference yield:

: 201274-07-9
L-threonine benzyl ester oxalate salt

: 1452389-56-8
2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 3 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 6 h / 20 °C / Inert atmosphere

3: triethylamine; triphenylphosphine; iodine / dichloromethane / 15 h / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iodine; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: |Dess-Martin Oxidation;
DOI:10.1002/anie.201302372