(S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

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Chemical Name:(S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine
CAS No.:1452389-57-9
Molecular Formula:C₃₃H₃₃N₅O₆S₂
Molecular Weight:659.787
Hs Code.:

Synonyms:(S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

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Chemical Property of (S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

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Technology Process of (S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

There total 6 articles about (S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1338605-42-7
C₁₈H₂₇N₃O₂S₂Sn

: 1452389-56-8
2-chloro-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

: 1452389-57-9
(S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 48h;
DOI:10.1002/anie.201302372

Reference yield:

: 503000-87-1
2-chloro-6-methoxypyridine-3-carboxylic acid

: 1452389-57-9
(S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 3 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 6 h / 20 °C / Inert atmosphere

3: triethylamine; triphenylphosphine; iodine / dichloromethane / 15 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 48 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iodine; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 2: |Dess-Martin Oxidation / 4: |Stille Cross Coupling;
DOI:10.1002/anie.201302372

Reference yield:

: 1452389-66-0
benzyl (S)-2-(2-chloro-6-methoxynicotamido)-3-oxobutanoate

: 1452389-57-9
(S)-2-[2'-(N-(tert-butoxycarbonyl)pyrrolidin-2-yl)-2,4'-bithiazol-4-yl]-6-methoxy-3-[4-(benzyloxycarbonyl)-5-methyloxazol-2-yl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; triphenylphosphine; iodine / dichloromethane / 15 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 48 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; triethylamine; triphenylphosphine; In 1,4-dioxane; dichloromethane; 2: |Stille Cross Coupling;
DOI:10.1002/anie.201302372