(R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester

Base Information

• Chemical Name: (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester
• CAS No.: 172585-57-8
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.195
• Mol file: 172585-57-8.mol

Synonyms:(R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester

Chemical Property of (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester

There total 17 articles about (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Isopropenyl acetate (108-22-5) + 1-(4-Fluorophenyl)ethanol (403-41-8) → (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester (172585-57-8)

Guidance literature:

With Candida antarctica lipase B; potassium tert-butylate; sodium carbonate; RuCl(CO)2(η⁵-C5Ph5); In tetrahydrofuran; toluene; at 20 ℃; for 72h;

DOI:10.1016/j.tetlet.2007.05.175

Reference yield: 99.0%

Resorcinol diacetate (108-58-7) + 1-(4-Fluorophenyl)ethanol (403-41-8) → (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester (172585-57-8)

Guidance literature:

With lipase Novozyme 435; In toluene; at 40 ℃; for 24h; optical yield given as %ee; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.tetlet.2010.02.152

Reference yield: 88.0%

1-(4-fluorophenyl)ethanone (403-42-9) + ethyl acetate (141-78-6) → (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester (172585-57-8)

Guidance literature:

With novozyme 435; dicarbonylhydro[2,5-di(trimethylsilyl)-3,4-butylene-1-hydroxy(η5-cyclopentadienyl)]iron; hydrogen; In toluene; at 90 ℃; under 750.075 Torr; enantioselective reaction; Schlenk technique; Enzymatic reaction;

DOI:10.1002/cssc.201700169

upstream raw materials:

Isopropenyl acetate

1-(4-Fluorophenyl)ethanol

acetic anhydride

1-(4-fluorophenyl)ethanone

Downstream raw materials:

(R)-1-(4-fluorophenyl)ethan-1-ol

Refernces

• 1、 -. "Optically active 2-amino-4-alkoxypyrimidnes derivatives as 5-HT2C agonists". Paragraph 0122; 0123. . Retrieved 2019/12/25.
• 2、 El-Sepelgy, Osama,Brzozowska, Aleksandra,Rueping, Magnus. "Asymmetric Chemoenzymatic Reductive Acylation of Ketones by a Combined Iron-Catalyzed Hydrogenation–Racemization and Enzymatic Resolution Cascade". . p. 1664 - 1668. Retrieved 2017/04/27.