C₁₈H₁₃F₃O

Base Information

• Chemical Name: C₁₈H₁₃F₃O
• CAS No.: 1387581-22-7
• Molecular Formula: C₁₈H₁₃F₃O
• Molecular Weight: 302.296
• Mol file: 1387581-22-7.mol

Synonyms:C₁₈H₁₃F₃O

Chemical Property of C₁₈H₁₃F₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₃F₃O

There total 3 articles about C₁₈H₁₃F₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + 1-Phenylbut-1-en-3-one (122-57-6) → C18H13F3O (1387581-22-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 4h;

DOI:10.1021/ol501503a

Reference yield:

benzaldehyde (100-52-7) + 4-(4-trifluoromethylphenyl)but-3-en-2-one (80992-93-4) → C18H13F3O (1387581-22-7)

Guidance literature:

With calcium hydroxide; In ethanol; water; at 80 ℃; for 48h; Inert atmosphere; Green chemistry;

DOI:10.1016/j.cclet.2018.01.035

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → C18H13F3O (1387581-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: calcium hydroxide / ethanol; water / 10 h / 50 °C / Inert atmosphere; Green chemistry

2: calcium hydroxide / ethanol; water / 48 h / 80 °C / Inert atmosphere; Green chemistry

With calcium hydroxide; In ethanol; water; 1: |Claisen-Schmidt Condensation / 2: |Claisen-Schmidt Condensation;

DOI:10.1016/j.cclet.2018.01.035

upstream raw materials:

4-Trifluoromethylbenzaldehyde

1-Phenylbut-1-en-3-one

benzaldehyde

4-(4-trifluoromethylphenyl)but-3-en-2-one