1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione

Base Information

• Chemical Name: 1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione
• CAS No.: 199279-10-2
• Molecular Formula: C₁₉H₁₇NO₇
• Molecular Weight: 371.346
• Mol file: 199279-10-2.mol

Synonyms:1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione

Chemical Property of 1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione

There total 1 articles about 1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

1,2-dimethoxy-4-<1-<(1,1-dimethylethyl)dimethylsilyloxy>ethenyl>benzene (79631-01-9) + 5-(2-Nitro-phenyl)-furan-2,3-dione (179243-01-7) → 2-(3,4-dimethoxyphenyl)-6-(2-nitrophenyl)-4H-pyran-4-one (199279-11-3) + 1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione (199279-10-2)

Guidance literature:

In toluene; at 100 ℃; for 1h;

DOI:10.3987/com-97-7924

Reference yield: 45.0%

1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione (199279-10-2) → 2-<2-(3,4-dimethoxyphenyl)-2-oxoethyl>quinolin-4-one (199279-13-5) + 1-(2-aminophenyl)-5-(3,4-dimethoxyphenyl)pentane-1,3,5-trione (199279-12-4)

Guidance literature:

With hydrogen; 10% palladium on active carbon; In tetrahydrofuran; for 5h;

DOI:10.3987/com-97-7924

Reference yield:

1-(3,4-dimethoxyphenyl)-5-(2-nitrophenyl)pentane-1,3,5-trione (199279-10-2) → galipine (525-68-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 45 percent / H₂ / 10 percent Pd-C / tetrahydrofuran / 5 h

2: tetra-n-butylammonium borohydride / CH₂Cl₂ / 1 h / Ambient temperature

3: AcOH / 1 h / Heating

4: CH₂Cl₂; diethyl ether / 17 h / Ambient temperature

5: 99 percent / H₂ / 10 percent Pd-C / methanol / 5 h

With tetra(n-butyl)ammonium borohydride; hydrogen; acetic acid; 10% palladium on active carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

DOI:10.3987/com-97-7924

upstream raw materials:

1,2-dimethoxy-4-<1-<(1,1-dimethylethyl)dimethylsilyloxy>ethenyl>benzene

5-(2-Nitro-phenyl)-furan-2,3-dione

Downstream raw materials:

2-<2-(3,4-dimethoxyphenyl)-2-oxoethyl>quinolin-4-one

1-(2-aminophenyl)-5-(3,4-dimethoxyphenyl)pentane-1,3,5-trione

galipine

dehydrogalipin