N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide

Base Information

Chemical Name:N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide
CAS No.:133041-77-7
Molecular Formula:C₂₉H₃₈N₂O₆
Molecular Weight:510.631
Hs Code.:

Synonyms:N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide

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Chemical Property of N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide

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Technology Process of N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide

There total 6 articles about N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 462-06-6
fluorobenzene

: 133041-77-7
N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / AlCl₃ / various solvent(s) / 4 h / 20 °C

2: 60 percent / dimethylsulfoxide / 5 h / 140 °C

3: D-camphorsulfonic acid / CH₂Cl₂ / 10 h / 20 °C

4: H₂ / Pd/C / methanol / 5 h

5: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

With aluminium trichloride; (1S)-10-camphorsulfonic acid; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00109a005

Reference yield:

: 2195-47-3
4-(4-fluorobenzoyl)-nitrobenzene

: 133041-77-7
N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / dimethylsulfoxide / 5 h / 140 °C

2: D-camphorsulfonic acid / CH₂Cl₂ / 10 h / 20 °C

3: H₂ / Pd/C / methanol / 5 h

4: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

With (1S)-10-camphorsulfonic acid; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00109a005

Reference yield:

: 133041-71-1
4--4'-nitrobenzophenone

: 133041-77-7
N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: D-camphorsulfonic acid / CH₂Cl₂ / 10 h / 20 °C

2: H₂ / Pd/C / methanol / 5 h

3: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

With (1S)-10-camphorsulfonic acid; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00109a005