2195-47-3

Basic information

• Product Name: 4-FLUORO-4'-NITROBENZOPHENONE
• Synonyms: (4-FLUOROPHENYL)(4-NITROPHENYL)METHANONE;4-FLUORO-4'-NITROBENZOPHENONE;4-FLUORO-4-NITROBENZOPHENONE;4-Fluoro-4'-nitrobenzophenone 98%;4-Fluoro-4'-nitrobenzophenone98%;4-Nitro-4'-fluorobenzophenone
• CAS NO: 2195-47-3
• Molecular Formula: C₁₃H₈FNO₃
• Molecular Weight: 245.21
• Mol File: 2195-47-3.mol
• Article Data: 21

Chemical Properties

• Melting Point: 87-89°C
• Boiling Point: 397.2 °C at 760 mmHg
• Flash Point: 194 °C
• Appearance: /
• Density: 1.335
• CAS DataBase Reference: 4-FLUORO-4'-NITROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-4'-NITROBENZOPHENONE(2195-47-3)
• EPA Substance Registry System: 4-FLUORO-4'-NITROBENZOPHENONE(2195-47-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 2195-47-3(Hazardous Substances Data)

Usage

General Description

4-Fluoro-4'-nitrobenzophenone is a chemical compound with the formula C13H8FNO3. It is a yellow crystalline solid commonly used as a pharmaceutical intermediate and in the synthesis of various organic compounds. 4-FLUORO-4'-NITROBENZOPHENONE is a derivative of benzophenone, which is a common building block in organic chemistry. The presence of a fluoro and a nitro group in its structure makes 4-Fluoro-4'-nitrobenzophenone a versatile compound for use in the preparation of dyes, pigments, and pharmaceuticals. It is also used in the production of specialty chemicals and advanced materials due to its unique reactivity and structural properties. Overall, 4-Fluoro-4'-nitrobenzophenone is a valuable chemical compound with diverse applications in the chemical and pharmaceutical industries.

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 98-95-3 nitrobenzene 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 1765-93-1 4-fluoroboronic acid 
• 122-04-3 4-nitro-benzoyl chloride 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 38695-21-5 (4-fluorophenyl)(4-nitrophenyl)methanol 
• 462-06-6 fluorobenzene 
• 101-81-5 Diphenylmethane 
• 1817-74-9 bis(4-nitrophenyl)methane 

Downstream Products

• 133041-71-1 4--4'-nitrobenzophenone 
• 10055-40-0 (4-aminophenyl)(4-fluorophenyl)methanone 
• 853566-88-8 (4-Nitro-phenyl)-(4-[1,2,3]triazol-2-yl-phenyl)-methanone 
• 853566-93-5 (4-Nitro-phenyl)-(4-[1,2,3]triazol-1-yl-phenyl)-methanone 
• 853566-99-1 (4-nitro-phenyl)-(4-[1,2,4] triazol-1-yl-phenyl)-methanone 
• 853567-05-2 (4-Imidazol-1-yl-phenyl)-(4-nitro-phenyl)-methanone 
• 64583-43-3 C₁₃H₉BrFNO₂ 
• 1841-50-5 4-Fluor-4'-nitro-diphenylmethylchlorid 
• 38695-23-7 1-(4-fluorobenzyl)-4-nitrobenzene 
• 133332-13-5 (4-{4-[Bis-(2-chloro-ethyl)-amino]-benzyl}-phenyl)-quinolin-4-yl-amine 
• 133041-77-7 N-[4-(4-{Bis-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-benzoyl)-phenyl]-acetamide 

Relevant articles and documents

Dirhodium-Catalyzed Enantioselective B?H Bond Insertion of gem-Diaryl Carbenes: Efficient Access to gem-Diarylmethine Boranes

The scarcity of reliable methods for synthesizing chiral gem-diarylmethine borons limits their applications. Herein, we report a method for highly enantioselective dirhodium-catalyzed B?H bond insertion reactions with diaryl diazomethanes as carbene precursors. These reactions afforded chiral gem-diarylmethine borane compounds in high yield (up to 99 % yield), high activity (turnover numbers up to 14 300), high enantioselectivity (up to 99 % ee) and showed unprecedented broad functional group tolerance. The borane compounds synthesized by this method could be efficiently transformed into diaryl methanol, diaryl methyl amine, and triaryl methane derivatives with good stereospecificity. Mechanistic studies suggested that the borane adduct coordinated to the rhodium catalyst and thus interfered with decomposition of the diazomethane, and that insertion of a rhodium carbene (generated from the diaryl diazomethane) into the B?H bond was most likely the rate-determining step.

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

At normal pressure fragrant ketone nickel catalytic synthesis method

The invention discloses a method for synthesizing diarylketone under the catalysis of nickel at normal pressure. The method comprises the steps of enabling aryl iodide, arylboronic acid and carbon monoxide to be subjected to direct cross-coupling reaction in a solvent polyethylene glycol or a water solution of polyethylene glycol under the catalysis of a nickel catalyst and the combined action of alkaline and acid at normal pressure to prepare a diarylketone compound. The method has the advantages of wide catalyst source, low price, little toxicity, reaction at normal pressure, high selectivity, no need of ligands in reaction, good activity, good functional group compatibility, wide substrate application range, wide substrate source, stable substrate, green and recyclable reaction medium and the like. The separation yield of target products is up to 93% under an optimized reaction condition.