2195-47-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Fluoro-4'-nitrobenzophenone is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows for the development of new pharmaceutical compounds with improved properties and therapeutic effects.
Used in Organic Synthesis:
In the field of organic chemistry, 4-Fluoro-4'-nitrobenzophenone is utilized as a key component in the synthesis of a wide range of organic compounds. Its reactivity and structural properties make it a valuable building block for creating new molecules with specific functions and applications.
Used in Dye and Pigment Production:
4-Fluoro-4'-nitrobenzophenone is employed as a starting material in the production of dyes and pigments. Its chemical structure contributes to the color and stability of these products, making it an essential component in the formulation of various dyes and pigments used in different industries.
Used in Specialty Chemicals and Advanced Materials:
Due to its unique reactivity and structural properties, 4-Fluoro-4'-nitrobenzophenone is used in the development and production of specialty chemicals and advanced materials. Its versatility allows for the creation of new materials with specific properties, such as improved thermal stability, chemical resistance, or enhanced performance in various applications.

Upstream product

• 462-06-6 fluorobenzene 
• 122-04-3 4-nitro-benzoyl chloride 
• 1817-74-9 bis(4-nitrophenyl)methane 
• 1765-93-1 4-fluoroboronic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 38695-21-5 (4-fluorophenyl)(4-nitrophenyl)methanol 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 98-95-3 nitrobenzene 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 101-81-5 Diphenylmethane 

Downstream Products

• 133041-71-1 4--4'-nitrobenzophenone 
• 347-82-0 4-nitro-benzoic acid-(4-fluoro-phenyl ester) 
• 10055-40-0 (4-aminophenyl)(4-fluorophenyl)methanone 
• 62-23-7 4-nitro-benzoic acid 
• 38695-23-7 1-(4-fluorobenzyl)-4-nitrobenzene 
• 1841-50-5 4-Fluor-4'-nitro-diphenylmethylchlorid 
• 64583-43-3 C₁₃H₉BrFNO₂ 
• 853566-88-8 (4-Nitro-phenyl)-(4-[1,2,3]triazol-2-yl-phenyl)-methanone 
• 853566-93-5 (4-Nitro-phenyl)-(4-[1,2,3]triazol-1-yl-phenyl)-methanone 
• 853566-99-1 (4-nitro-phenyl)-(4-[1,2,4] triazol-1-yl-phenyl)-methanone 
• 853567-05-2 (4-Imidazol-1-yl-phenyl)-(4-nitro-phenyl)-methanone 

Relevant academic research and scientific papers

Dirhodium-Catalyzed Enantioselective B?H Bond Insertion of gem-Diaryl Carbenes: Efficient Access to gem-Diarylmethine Boranes

The scarcity of reliable methods for synthesizing chiral gem-diarylmethine borons limits their applications. Herein, we report a method for highly enantioselective dirhodium-catalyzed B?H bond insertion reactions with diaryl diazomethanes as carbene precursors. These reactions afforded chiral gem-diarylmethine borane compounds in high yield (up to 99 % yield), high activity (turnover numbers up to 14 300), high enantioselectivity (up to 99 % ee) and showed unprecedented broad functional group tolerance. The borane compounds synthesized by this method could be efficiently transformed into diaryl methanol, diaryl methyl amine, and triaryl methane derivatives with good stereospecificity. Mechanistic studies suggested that the borane adduct coordinated to the rhodium catalyst and thus interfered with decomposition of the diazomethane, and that insertion of a rhodium carbene (generated from the diaryl diazomethane) into the B?H bond was most likely the rate-determining step.

Synthesis, structure, and characterization of picolyl- and benzyl-linked biphenyl palladium N-heterocyclic carbene complexes and their catalytic activity in acylative cross-coupling reactions

N-heterocyclic carbene ligands with picolyl (L1H2Br2, L3H2Br2) and benzyl (L2H2Br2, L4H2Br2) linked biphenyl backbone were synthesized and characterized. Their palladium(II) complexes [PdL1]Br2 (1), [PdL2Br2] (2), [PdL3]Br2 (3), and [PdL4Br2] (4) were synthesized by direct method using Pd(OAc)2. All complexes (1–4) were characterized by CHN analysis, electrospray ionization-MS, nuclear magnetic resonance, and single-crystal X-ray diffraction. Molecular structures confirm the distorted square planar geometry around the Pd(II) center. All of them showed good catalytic activity in acylative Suzuki cross coupling of phenyl boronic acid with benzoyl chloride to afford benzophenone in good yields.

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

Transition-Metal-Free Regiospecific Aroylation of Nitroarenes Using Ethyl Arylacetates at Room Temperature

A novel regiospecific C(sp3)-C(sp2) coupling between ethyl arylacetates and nitroarenes has been developed to deliver biaryl ketones in excellent yields. The protocol is metal-free, mild, and compatible with a number of functional groups on both of the reacting partners.

At normal pressure fragrant ketone nickel catalytic synthesis method

The invention discloses a method for synthesizing diarylketone under the catalysis of nickel at normal pressure. The method comprises the steps of enabling aryl iodide, arylboronic acid and carbon monoxide to be subjected to direct cross-coupling reaction in a solvent polyethylene glycol or a water solution of polyethylene glycol under the catalysis of a nickel catalyst and the combined action of alkaline and acid at normal pressure to prepare a diarylketone compound. The method has the advantages of wide catalyst source, low price, little toxicity, reaction at normal pressure, high selectivity, no need of ligands in reaction, good activity, good functional group compatibility, wide substrate application range, wide substrate source, stable substrate, green and recyclable reaction medium and the like. The separation yield of target products is up to 93% under an optimized reaction condition.

Transition metal-free Suzuki type cross-coupling reaction for the synthesis of dissymmetric ketones

A simple, efficient and metal-free route for the synthesis of dissymmetric ketones through Suzuki type cross-coupling reaction has been established. This strategy signifies an attractive, cost-effective and operationally convenient tool for the synthesis of a wide range of dissymmetric ketones. Although conventional routes for the synthesis of ketones have been widely used, the potential challenge with these methods is functional group tolerance. The reported metal-free method represents a reaction with moderate functional group tolerance. The procedure is operationally convenient and shows broad substrate scope with good to excellent product yields.

KCC-1 supported palladium nanoparticles as an efficient and sustainable nanocatalyst for carbonylative Suzuki-Miyaura cross-coupling

This work reports a cost-effective and sustainable protocol for the carbonylative Suzuki-Miyaura cross-coupling reaction catalyzed by palladium nanoparticles (Pd NPs) supported on fibrous nanosilica (KCC-1). Under mild reaction conditions, the KCC-1-PEI/Pd catalytic system showed a turnover number (TON) 28-times and a turnover frequency (TOF) 51-times higher than the best supported Pd catalyst reported in the literature for the carbonylative cross-coupling between 4-iodoanisole and phenylboronic acid, as a test reaction. Also, the catalyst could be recycled up to ten times with a marginal loss in activity after the eighth cycle. The high activity of the catalyst can be attributed to the fibrous nature of the KCC-1 support and PEI functionalization provided the enhanced stability.

Copper-catalyzed arylation of arylboronic acids with aldehydes

A novel copper-catalyzed arylation of arylboronic acids with aldehydes under oxygen atmosphere was achieved in the presence of Cu(OTf)2 and Xantphos, affording diaryl ketone derivatives in moderate to good yields. The efficiency of this reaction was demonstrated by the compatibility with fluoro, bromo, chloro, nitro, -methylsulfonyl, and trifluoromethyl groups. Georg Thieme Verlag Stuttgart ? New York.

Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities

A new class of 4β-N-polyaromatic substituted podophyllotoxin congeners have been synthesized and evaluated for their DNA topoisomerase-II (topo-II) inhibition as well as anticancer potential in some human cancer cell lines. The ease of synthesis and inter

A novel Br?nsted acid catalyst for Friedel-Crafts acylation

Bis(trifluoroalkylsulfonylimino)trifluoromethanesulfonic acid has demonstrated remarkable catalytic ability in the electrophilic acylation of aromatic substrates. Various perfluoroalkyl substituted aroyl chlorides are employed in Friedel-Crafts acylation typically using 1 mol % of catalyst. Crown Copyright