1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione

Base Information

Chemical Name:1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione
CAS No.:1414778-61-2
Molecular Formula:C₂₃H₁₉N₅O₄S
Molecular Weight:461.501
Hs Code.:

Synonyms:1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione

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Chemical Property of 1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione

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Technology Process of 1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione

There total 3 articles about 1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1414778-37-2
ethyl 6-{[(3-cyano-5,6,7,8-tetrahydroquinolin-2-yl)thio]methyl}-1-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1414778-61-2
1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.166667h; Reflux;
DOI:10.1016/j.tet.2012.09.041

Reference yield:

: 219814-84-3
1,6-dimethyl-4-(3-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

: 1414778-61-2
1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine

2.1: potassium hydroxide / water; N,N-dimethyl-formamide / 0.17 h

2.2: 50 - 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Reflux

With bromine; sodium hydride; potassium hydroxide; In water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.09.041

Reference yield:

: 300852-76-0
6-bromomethyl-5-ethoxycarbonyl-1-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

: 1414778-61-2
1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / water; N,N-dimethyl-formamide / 0.17 h

1.2: 50 - 70 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Reflux

With sodium hydride; potassium hydroxide; In water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.09.041