219814-84-3

Basic information

• Product Name: 1,6-DIMETHYL-4-(3-NITRO-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 1,6-DIMETHYL-4-(3-NITRO-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 219814-84-3
• Molecular Formula: C₁₅H₁₇N₃O₅
• Molecular Weight: 319.31
• Mol File: 219814-84-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,6-DIMETHYL-4-(3-NITRO-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-DIMETHYL-4-(3-NITRO-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER(219814-84-3)
• EPA Substance Registry System: 1,6-DIMETHYL-4-(3-NITRO-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER(219814-84-3)

Safety Data

• Hazardous Substances Data: 219814-84-3(Hazardous Substances Data)

Upstream product

• 123371-44-8 nifetepimine 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 141-97-9 ethyl acetoacetate 
• 99-61-6 3-nitro-benzaldehyde 
• 598-50-5 N-Methylurea 

Downstream Products

• 1414778-67-8 1-methyl-4-(3-nitrophenyl)-7,9-diphenyl-4,6-dihydropyrido[3,2:4',5']thieno[2',3':5,6]pyrido[4,3-d]pyrimidine-2,5(1H,3H)-dione 
• 1414778-61-2 1-methyl-4-(3-nitrophenyl)-4,6,8,9,10,11-hexahydropyrimido[4,5:4',5']pyrido[2',3':4,5]thieno[2,3-b]quinoline-2,5(1H,3H)-dione 
• 1414778-37-2 ethyl 6-{[(3-cyano-5,6,7,8-tetrahydroquinolin-2-yl)thio]methyl}-1-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1414778-44-1 ethyl 6-{[(3-cyano-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)thio]methyl}-1-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1391631-77-8 ethyl 6-{[3-cyano-4-(2,5-dimethoxyphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-ylthio]methyl}-1-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 300852-76-0 6-bromomethyl-5-ethoxycarbonyl-1-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one 

Relevant articles and documents

Cerous p-Toluenesulfonate as an Efficient and Recyclable Catalyst for the Synthesis of N1-Substituted-4-aryl-3,4-dihydropyrimidin-2(1H)-ones

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N-substituted ureas and thioureas in Biginelli reaction promoted by chlorotrimethylsilane: Convenient synthesis of N1-alkyl-, N1-aryl-, and N1,N3-dialkyl-3,4-dihydropyrimidin-2(1H)-(thi)ones

The classical Biginelli reaction has been extended by the use of N-substituted ureas and thioureas. A set of N1-alkyl-, N1-aryl-, and N1,N3-dialkyl-3,4-dihydropyrimidin-2(1H)-(thi)ones was readily prepared in excellent yield when chlorotrimethylsilane in

Selective N1-alkylation of 3,4-dihydropyrimidin-2(1H)-ones using Mitsunobu-type conditions

The regioselective N1-alkylation of 3,4-dihydropyrimidin-2(1H)-ones via Mitsunobu reaction is reported. Using the highly reactive Mitsunobu coupling reagent combination N,N,N′,N′-tetramethylazodicarboxamide/tributylphosphine (TMAD-TBP) and a set of primary alcohols a small library of N1-alkylated dihydropyrimidones is obtained in good to excellent yields.