tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate
CAS No.:1369358-06-4
Molecular Formula:C₃₄H₄₅N₃O₇
Molecular Weight:607.747
Hs Code.:

Synonyms:tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1369358-04-2
2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)-2-(methoxymethoxy)phenyl)acetic acid

: 160587-12-2
1-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

: 1369358-06-4
tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 19h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.02.019

Reference yield:

: C₂₄H₃₆N₂O₆S

: 1369358-06-4
tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 24 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.019

Reference yield:

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 1369358-06-4
tert-butyl 4-(3-(methoxymethoxy)-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 h / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: sulfur / 5 h / 135 - 140 °C

4: sodium hydroxide / methanol; water / 24 h / Reflux

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; caesium carbonate; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; 3: Wilgerodt-Kindler reaction;
DOI:10.1016/j.bmc.2012.02.019