1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone

Base Information

Chemical Name:1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone
CAS No.:1369357-99-2
Molecular Formula:C₃₀H₃₈FN₃O₆S
Molecular Weight:587.713
Hs Code.:

Synonyms:1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone

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Chemical Property of 1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone

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Technology Process of 1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone

There total 9 articles about 1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 762-49-2
2-fluoroethyl bromide

: 1369358-09-7
1-(1-(2-(2-hydroxy-4-(1-(methylsulfonyl)piperidin-4-yloxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

: 1369357-99-2
1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 19h;
DOI:10.1016/j.bmc.2012.02.019

Reference yield:

: 1369358-04-2
2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)-2-(methoxymethoxy)phenyl)acetic acid

: 1369357-99-2
1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

2: hydrogenchloride / diethyl ether; dichloromethane / 12 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 14 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.019

Reference yield:

: 1369358-02-0
tert-butyl 4-(4-acetyl-3-(methoxymethoxy)phenoxy)piperidine-1-carboxylate

: 1369357-99-2
1-(4-(3,4-dihydro-2-oxoquinolin-1(2H)-yl)piperidin-1-yl)-2-(2-(2-fluoroethoxy)-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: sulfur / 5 h / 135 - 140 °C

2: sodium hydroxide / methanol; water / 24 h / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

4: hydrogenchloride / diethyl ether; dichloromethane / 12 h / 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 14 h / 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; caesium carbonate; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 1: Wilgerodt-Kindler reaction;
DOI:10.1016/j.bmc.2012.02.019