1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

Base Information

Chemical Name:1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one
CAS No.:1369358-01-9
Molecular Formula:C₂₉H₃₇N₃O₆S
Molecular Weight:555.695
Hs Code.:

Synonyms:1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

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Chemical Property of 1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

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Technology Process of 1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

There total 9 articles about 1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1369358-09-7
1-(1-(2-(2-hydroxy-4-(1-(methylsulfonyl)piperidin-4-yloxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

: 74-88-4
methyl iodide

: 1369358-01-9
1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.02.019

Reference yield:

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 1369358-01-9
1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 h / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: sulfur / 5 h / 135 - 140 °C

4: sodium hydroxide / methanol; water / 24 h / Reflux

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

6: hydrogenchloride / diethyl ether; dichloromethane / 12 h / 20 °C / Inert atmosphere

7: triethylamine / dichloromethane / 14 h / 20 °C

8: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; caesium carbonate; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3: Wilgerodt-Kindler reaction;
DOI:10.1016/j.bmc.2012.02.019

Reference yield:

: 1369358-04-2
2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)-2-(methoxymethoxy)phenyl)acetic acid

: 1369358-01-9
1-(1-(2-(2-methoxy-4-((1-(methylsulfonyl)piperidin-4-yl)oxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

2: hydrogenchloride / diethyl ether; dichloromethane / 12 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 14 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.019