(2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate

Base Information

• Chemical Name: (2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate
• CAS No.: 482631-85-6
• Molecular Formula: C₃₄H₃₃NO₄
• Molecular Weight: 519.64
• Mol file: 482631-85-6.mol

Synonyms:(2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate

Chemical Property of (2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate

There total 3 articles about (2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

benzyl bromide (100-39-0) + 2-(9-phenyl-9H-fluoren-9-ylamino)-succinic acid 4-tert-butyl ester (482632-06-4) → (2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate (482631-85-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/S0968-0896(02)00206-7

Reference yield:

9-bromo-9-phenyl-9H-fluorene (55135-66-5) → (2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate (482631-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylchlorosilane / CH₂Cl₂ / 2 h / 20 °C

1.2: 90 percent / PbNO₃; Et₃N / CH₂Cl₂ / 72 h / 20 °C

2.1: 68 percent / Cs₂CO₃ / dimethylformamide / 3 h / 20 °C

With chloro-trimethyl-silane; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(02)00206-7

Reference yield:

L-Asp(t-Bu) (3057-74-7) → (2S)-1-benzyl 4-tert-butyl 2-(((9H-fluoren-9-yl)(phenyl)methyl)amino)succinate (482631-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylchlorosilane / CH₂Cl₂ / 2 h / 20 °C

1.2: 90 percent / PbNO₃; Et₃N / CH₂Cl₂ / 72 h / 20 °C

2.1: 68 percent / Cs₂CO₃ / dimethylformamide / 3 h / 20 °C

With chloro-trimethyl-silane; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(02)00206-7

upstream raw materials:

benzyl bromide

2-(9-phenyl-9H-fluoren-9-ylamino)-succinic acid 4-tert-butyl ester

9-bromo-9-phenyl-9H-fluorene

L-Asp(t-Bu)