(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin

Base Information

Chemical Name:(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin
CAS No.:1560773-61-6
Molecular Formula:C₃₂H₃₄N₂O₈
Molecular Weight:574.631
Hs Code.:

Synonyms:(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin

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Chemical Property of (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin

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Technology Process of (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin

There total 9 articles about (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1560773-49-0
4-(3-amino-4-methoxyphenyl)-5-methoxycoumarin

: 23680-31-1
BOC-O-benzyl-L-serine

: 1560773-61-6
(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 15h; Inert atmosphere;
DOI:10.1007/s11172-013-0149-3

Reference yield:

: 262433-23-8
2-(3-tert-butoxycarbonylamino-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1560773-61-6
(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 17 h / 20 - 110 °C / Inert atmosphere

2.1: hydrogenchloride; ethanol / ethyl acetate / 50 °C

2.2: 0.5 h / 20 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 20 - 50 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1007/s11172-013-0149-3

Reference yield:

: 53666-76-5
4-hydroxy-5-methoxy-2H-chromen-2-one

: 1560773-61-6
(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.1: potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 17 h / 20 - 110 °C / Inert atmosphere

3.1: hydrogenchloride; ethanol / ethyl acetate / 50 °C

3.2: 0.5 h / 20 °C

4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 20 - 50 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1007/s11172-013-0149-3