N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine

Base Information

• Chemical Name: N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine
• CAS No.: 1092690-86-2
• Molecular Formula: C₃₀H₃₅NO₆S
• Molecular Weight: 537.677
• Mol file: 1092690-86-2.mol

Synonyms:N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine

Chemical Property of N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine

There total 4 articles about N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + N-(4-biphenylsulfonyl)-O-benzyl-D-valine (1092690-84-0) → N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine (1092690-86-2)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1021/jm800964f

Reference yield:

D-Val-OH (640-68-6,25609-85-2,7004-03-7,921-10-8) → N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine (1092690-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / 1,4-dioxane; water / 20 °C

2: triethylamine / acetonitrile / Reflux

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; triethylamine; potassium iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm200593b

Reference yield:

4-diphenylsulfonyl chloride (1623-93-4) → N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine (1092690-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / 1,4-dioxane; water / 20 °C

2: triethylamine / acetonitrile / Reflux

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; triethylamine; potassium iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm200593b

upstream raw materials:

bromoacetic acid tert-butyl ester

N-(4-biphenylsulfonyl)-O-benzyl-D-valine

benzyl bromide

D-Val-OH

Downstream raw materials:

N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

N-(4-biphenylsulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

(R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione

(R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione