(R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione

Base Information

Chemical Name:(R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione
CAS No.:1203835-15-7
Molecular Formula:C₂₆H₂₆N₂O₅S
Molecular Weight:478.569
Hs Code.:

Synonyms:(R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione

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Chemical Property of (R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione

Chemical Property:

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Technology Process of (R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione

There total 9 articles about (R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1092690-95-3
N-(4-biphenylsulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

: 1203835-15-7
(R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione

Guidance literature:: With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jm200593b

Reference yield:

: (R)-2-(biphenyl-4-ylsulfonamido)-3-methylbutanoic acid

: 1203835-15-7
(R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / acetonitrile / Reflux

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4: 4-methyl-morpholine / tetrahydrofuran / 0 °C

5: methanol / 0 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

7: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200593b

Reference yield:

: 1092690-86-2
N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine

: 1203835-15-7
(R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2: 4-methyl-morpholine / tetrahydrofuran / 0 °C

3: methanol / 0 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm200593b