(R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione

Base Information

• Chemical Name: (R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione
• CAS No.: 1203835-07-7
• Molecular Formula: C₁₉H₂₀N₂O₅S
• Molecular Weight: 388.444
• Mol file: 1203835-07-7.mol

Synonyms:(R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione

Chemical Property of (R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione

There total 10 articles about (R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(R)-1-(benzyloxy)-4-(biphenyl-4-ylsulfonyl)-3-isopropylpiperazine-2,6-dione (1203835-15-7) → (R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione (1203835-07-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 3h; under 1125.11 Torr;

DOI:10.1021/jm200593b

Reference yield:

N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine (1092690-86-2) → (R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione (1203835-07-7)

Guidance literature:

Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2: 4-methyl-morpholine / tetrahydrofuran / 0 °C

3: methanol / 0 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 1125.11 Torr

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm200593b

Reference yield:

N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-D-valine (1092690-89-5) → (R)-4-(biphenyl-4-ylsulfonyl)-1-hydroxy-3-isopropylpiperazine-2,6-dione (1203835-07-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0 °C

2: methanol / 0 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 1125.11 Torr

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm200593b

upstream raw materials:

N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine

N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-D-valine

N-(4-biphenylsulfonyl)-O-benzyl-D-valine

N-(4-biphenylsulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid