(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane

Base Information

Chemical Name:(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane
CAS No.:1235570-35-0
Molecular Formula:C₂₉H₄₄O₄S₂Si
Molecular Weight:548.883
Hs Code.:

Synonyms:(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane

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Chemical Property of (2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane

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Technology Process of (2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane

There total 4 articles about (2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1235570-48-5
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol

: 74-88-4
methyl iodide

: 1235570-35-0
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/c0cc00056f

Reference yield:

: 1235570-42-9
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

: 1235570-35-0
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane;
DOI:10.1021/jo201729t

Reference yield:

: 92512-41-9
C₂₁H₂₈O₃Si

: 1235570-35-0
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 48 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -20 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C

With n-butyllithium; potassium tert-butylate; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo201729t