4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate

Base Information

Chemical Name:4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate
CAS No.:1379604-36-0
Molecular Formula:C₇H₈O₃S*C₁₇H₁₆FN₅O
Molecular Weight:497.55
Hs Code.:

Synonyms:4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate

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Chemical Property of 4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate

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Technology Process of 4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate

There total 7 articles about 4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379603-70-9
tert-butyl 4-{5-cyano-4-[(4-cyano-2-fluorophenoxy)methyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate

: 104-15-4
toluene-4-sulfonic acid

: 1379604-36-0
4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate

Guidance literature:: In 2-methyltetrahydrofuran; at 75 ℃; for 8h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1379604-36-0
4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 19 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.75 h / -78 - -10 °C

2.2: 20 h / -10 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; 2-methyltetrahydrofuran / 8 h / 20 °C / Inert atmosphere

4.1: 2-methyltetrahydrofuran / 8 h / 75 °C

With diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2-methyltetrahydrofuran; toluene;

Reference yield:

: 1258001-22-7
tert-butyl 4-(5-bromo-4-ethoxycarbonylpyrazol-1-yl)piperidine-1-carboxylate

: 1379604-36-0
4-[(4-cyano-2-fluorophenoxy)methyl]-1-piperidin-4-yl-1H-pyrazole-5-carbonitrile tosylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 15 h / 0 - 20 °C / Reflux

1.2: 0.33 h / 20 °C / Cooling with ice

2.1: N,N-dimethyl-formamide / 4 h / 165 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; 2-methyltetrahydrofuran / 8 h / 20 °C / Inert atmosphere

4.1: 2-methyltetrahydrofuran / 8 h / 75 °C

With dimethylsulfide borane complex; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2-methyltetrahydrofuran; N,N-dimethyl-formamide; toluene;