2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol

Base Information

Chemical Name:2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol
CAS No.:77405-72-2
Molecular Formula:C₃₃H₃₀N₂O₄
Molecular Weight:518.612
Hs Code.:

Synonyms:2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol

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Chemical Property of 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol

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Technology Process of 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol

There total 11 articles about 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 77405-71-1
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline

: 77405-72-2
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 1h;
DOI:10.1021/ja00395a071

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 77405-72-2
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃, KI / dimethylformamide / 14 h / Ambient temperature

2: benzene / 14 h / Heating

3: Na₂S / methanol / 2 h / Heating

4: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

5: 85 percent / TFA / 1 h / 0 °C

With sodium sulfide; potassium tert-butylate; potassium carbonate; trifluoroacetic acid; potassium iodide; In methanol; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/ja00395a071

Reference yield:

: 92541-05-4
(Z)-3-Amino-1-(2-benzyloxy-3,4-dimethoxy-phenyl)-2-methyl-but-2-en-1-one

: 77405-72-2
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / xylene / 14 h / Heating

2: NaBH₄ / tetrahydrofuran; propan-2-ol / 16 h / Ambient temperature

3: 67 percent / PhPOCl₂ / 3 h / 170 °C

4: 85 percent / dimethylformamide / 14 h / Heating

5: 2.) H₂O, H⁽¹⁺⁾ / 1) C₆H₆, room temperature, 1.5 h

6: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

7: 85 percent / TFA / 1 h / 0 °C

With P,P-dichlorophenylphosphine oxide; sodium tetrahydroborate; potassium tert-butylate; water; hydrogen cation; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol; toluene; xylene; tert-butyl alcohol;
DOI:10.1021/ja00395a071