(2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

Base Information

Chemical Name:(2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine
CAS No.:1572928-23-4
Molecular Formula:C₂₃H₂₆N₂S
Molecular Weight:362.539
Hs Code.:

Synonyms:(2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

Chemical Property:

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Technology Process of (2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

There total 8 articles about (2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 411229-63-5
1-bromo-4-(cyclopropylsulfanyl)benzene

: 1450620-25-3
(3S)-1-benzyl-3-(1-propyn-1-yl)piperazine

: 1572928-23-4
(2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; ruphos; In 1,4-dioxane; at 80 - 100 ℃; Inert atmosphere;
DOI:10.1021/jm5000497

Reference yield:

: 106-53-6
para-bromobenzenethiol

: 1572928-23-4
(2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide / 12 h / 20 - 100 °C / Inert atmosphere

2: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 20 - 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; sodium t-butanolate; ruphos; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 1572928-23-4
(2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

4: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

5: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 20 - 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;