tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

Base Information

Chemical Name:tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate
CAS No.:1572928-26-7
Molecular Formula:C₂₆H₃₂N₄O₅S₂
Molecular Weight:544.696
Hs Code.:

Synonyms:tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

There total 17 articles about tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1572928-25-6
tert-butyl (5-(((3S)-4-(4-(cyclopropylsulfanyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

: 1572928-26-7
tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: With dihydrogen peroxide; acetic acid; at 0 - 20 ℃; for 1.58333h;
DOI:10.1021/jm5000497

Reference yield:

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: 1572928-26-7
tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: dihydrogen peroxide; acetic acid / water / 1.5 h / 0 - 20 °C

With pyridine; dihydrogen peroxide; acetic acid; In dichloromethane; water;

Reference yield:

: 106-53-6
para-bromobenzenethiol

: 1572928-26-7
tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 12 h / 20 - 100 °C / Inert atmosphere

2.1: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 20 - 100 °C / Inert atmosphere

3.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C

3.2: 2 h / 80 °C

4.1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: dihydrogen peroxide; acetic acid / water / 1.5 h / 0 - 20 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; dihydrogen peroxide; potassium carbonate; acetic acid; sodium t-butanolate; ruphos; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;