1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide

Base Information

• Chemical Name: 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide
• CAS No.: 1322724-59-3
• Molecular Formula: C₁₉H₂₄ClN₅OS
• Molecular Weight: 405.951

Synonyms:1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide

Chemical Property of 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide

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Technology Process of 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide

There total 2 articles about 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl] acetic acid hydrazide (1322724-40-2) + isothiocyanatocyclohexane (1122-82-3) → 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide (1322724-59-3)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1007/s00044-011-9691-4

Reference yield:

[5-(4-chloro-phenyl)-3-methyl-pyrazol-1-yl]-acetic acid ethyl ester (63570-02-5) → 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide (1322724-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / Reflux

2: ethanol / 6 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-011-9691-4

Reference yield: 70.0%

1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide (1322724-59-3) + 4-(bromoacetyl)toluene (619-41-0) → 2-(5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl)-N'-(3-cyclohexyl-4-(p-tolyl)thiazol-2(3H)-ylidene)acetohydrazide

Guidance literature:

With triethylamine; In ethanol; for 3h; Reflux;

DOI:10.1016/j.bioorg.2021.104883

upstream raw materials:

[5-(4-chloro-phenyl)-3-methyl-pyrazol-1-yl]-acetic acid ethyl ester

2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl] acetic acid hydrazide

isothiocyanatocyclohexane

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