benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

Base Information

• Chemical Name: benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid
• CAS No.: 946522-94-7
• Molecular Formula: C₂₁H₂₄ClN₃O₃
• Molecular Weight: 401.893
• Mol file: 946522-94-7.mol

Synonyms:benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

Chemical Property of benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

There total 1 articles about benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-[(4-chlorophenyl)methyl]piperazine (23145-88-2) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid (946522-94-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

DOI:10.1021/jm070443e

Reference yield:

benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid (946522-94-7) → C13H18ClN3O

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2585.81 Torr;

DOI:10.1021/jm070443e

Reference yield:

benzyl ester of {2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}carbamic acid (946522-94-7) → C22H23N4O3SCl

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 3 h / 2585.81 Torr

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm070443e

upstream raw materials:

1-[(4-chlorophenyl)methyl]piperazine

N-(Benzyloxycarbonyl)glycine

Refernces