dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate

Base Information

• Chemical Name: dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate
• CAS No.: 1381757-31-8
• Molecular Formula: C₂₀H₃₀O₇
• Molecular Weight: 382.454
• Mol file: 1381757-31-8.mol

Synonyms:dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate

Chemical Property of dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate

There total 3 articles about dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl isopropylmalonate (759-36-4) + sodium methylate (124-41-4) + 4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene (172900-73-1) → dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate (1381757-31-8)

Guidance literature:

In toluene; at 85 - 90 ℃; for 2h;

Reference yield:

[4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol (172900-74-2) → dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate (1381757-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus tribromide / dichloromethane / 2 h / 0 - 10 °C

2: toluene / 2 h / 85 - 90 °C

With phosphorus tribromide; In dichloromethane; toluene;

Reference yield:

3-hydroxy-4-methoxybenzyl alcohol (4383-06-6) → dimethyl-2(4-methoxy-3-(3-methoxypropyloxy)-benzyl)-2-isopropyl malonate (1381757-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 10 h / 25 - 35 °C / Reflux

2: phosphorus tribromide / dichloromethane / 2 h / 0 - 10 °C

3: toluene / 2 h / 85 - 90 °C

With phosphorus tribromide; potassium carbonate; In dichloromethane; toluene; acetonitrile;

upstream raw materials:

diethyl isopropylmalonate

sodium methylate

4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene

3-hydroxy-4-methoxybenzyl alcohol

Downstream raw materials:

(R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol

(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid

2-isopropyl-3-{2-[3-methoxy(propyloxy)]-4-methoxyphenyl}propionic acid

(R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene