{1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester
CAS No.:908127-99-1
Molecular Formula:C₂₆H₃₇N₃O₆S₂
Molecular Weight:551.728
Hs Code.:

{1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester

There total 4 articles about {1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 288-47-1
1,3-thiazole

: 209796-51-0
{(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester

: 908127-99-1
{1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -40 ℃;
DOI:10.1016/S0960-894X(00)00636-3

Reference yield:

: 336870-02-1
(S)-tert-butoxycarbonylamino-(trans-4-hydroxy-cyclohexyl)-acetic acid

: 908127-99-1
{1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / DIEA; BOP / dimethylformamide

2.1: 73 percent / TPAP; N-methylmorpholine N-oxide; molecular sieves 4A / CH₂Cl₂

3.1: ammonium acetate; NaCNBH₃; molecular sieves 4 Angstroem / propan-2-ol

3.2: 38 percent / DMAP; DIEA / CH₂Cl₂

4.1: 75 percent / n-BuLi / tetrahydrofuran / -40 °C

With ammonium acetate; n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/S0960-894X(00)00636-3

Reference yield:

: 209796-49-6
[(methoxy-methyl-carbamoyl)-(4-oxo-cyclohexyl)-methyl]-carbamic acid tert-butyl ester

: 908127-99-1
{1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; NaCNBH₃; molecular sieves 4 Angstroem / propan-2-ol

1.2: 38 percent / DMAP; DIEA / CH₂Cl₂

2.1: 75 percent / n-BuLi / tetrahydrofuran / -40 °C

With ammonium acetate; n-butyllithium; 4 A molecular sieve; sodium cyanoborohydride; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1016/S0960-894X(00)00636-3