C₃₄H₂₉F₆N₃O₃

Base Information

• Chemical Name: C₃₄H₂₉F₆N₃O₃
• CAS No.: 691875-73-7
• Molecular Formula: C₃₄H₂₉F₆N₃O₃
• Molecular Weight: 641.613
• Mol file: 691875-73-7.mol

Synonyms:C₃₄H₂₉F₆N₃O₃

Chemical Property of C₃₄H₂₉F₆N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₂₉F₆N₃O₃

There total 7 articles about C₃₄H₂₉F₆N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

C25H24N2O4 + [3,5-bis(trifluoromethyl)phenyl]methanamine hydrochloride (42365-62-8) → C34H29F6N3O3 (691875-73-7)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

C26H26N2O4 (691877-48-2) → C34H29F6N3O3 (691875-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. LiOH / dioxane

2: 1-[(3-dimethylamino)propyl]-3-ethyl-carbodiimide; HOAT / CH₂Cl₂

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2006.07.011

Reference yield:

phthalic anhydride (85-44-9) → C34H29F6N3O3 (691875-73-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene / 6 h / Heating

2.1: diethyl ether

3.1: O₃ / CH₂Cl₂ / -78 °C

3.2: dimethyl sulfide / CH₂Cl₂ / 20 °C

4.1: sodium triacetoxyborohydride / 1,2-dichloro-ethane

5.1: aq. LiOH / dioxane

6.1: 1-[(3-dimethylamino)propyl]-3-ethyl-carbodiimide; HOAT / CH₂Cl₂

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium tris(acetoxy)borohydride; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; diethyl ether; dichloromethane; 1,2-dichloro-ethane; toluene;

DOI:10.1016/j.bmcl.2006.07.011

upstream raw materials:

3,5-bis-trifluoromethylbenzylamine

C₂₆H₂₆N₂O₄

phthalic anhydride

2-(1,3-dioxoisoindolin-2-yl)pent-4-enoic acid

Downstream raw materials:

C₂₆H₂₇F₆N₃O