C₂₂H₂₀ClFN₂O₄

Base Information

• Chemical Name: C₂₂H₂₀ClFN₂O₄
• CAS No.: 1415022-87-5
• Molecular Formula: C₂₂H₂₀ClFN₂O₄
• Molecular Weight: 430.863
• Mol file: 1415022-87-5.mol

Synonyms:C₂₂H₂₀ClFN₂O₄

Chemical Property of C₂₂H₂₀ClFN₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀ClFN₂O₄

There total 3 articles about C₂₂H₂₀ClFN₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

C23H22ClFN2O4 (1415022-92-2) → C22H20ClFN2O4 (1415022-87-5)

Guidance literature:

With sodium hydroxide; for 5h; Reflux;

DOI:10.1016/j.bmc.2012.09.065

Reference yield:

2-Bromo-5-fluorobenzoic acid (394-28-5) → C22H20ClFN2O4 (1415022-87-5)

Guidance literature:

Multi-step reaction with 6 steps

1: sulfuric acid / 4 h / Reflux

2: palladium diacetate; potassium carbonate; triphenylphosphine / 5 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / cyclohexane / 3 h / Reflux

4: potassium carbonate / acetonitrile / 6 h / 50 °C / Inert atmosphere; Reflux

5: sodium hypochlorite; sodium dihydrogenphosphate / butan-1-ol; water / 10 h

6: sodium hydroxide / 5 h / Reflux

With sodium hypochlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; In cyclohexane; water; acetonitrile; butan-1-ol; 2: |Suzuki Coupling;

DOI:10.1016/j.bmc.2012.09.065

Reference yield:

methyl 2-bromo-5-fluorobenzoate (6942-39-8) → C22H20ClFN2O4 (1415022-87-5)

Guidance literature:

Multi-step reaction with 5 steps

1: palladium diacetate; potassium carbonate; triphenylphosphine / 5 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / cyclohexane / 3 h / Reflux

3: potassium carbonate / acetonitrile / 6 h / 50 °C / Inert atmosphere; Reflux

4: sodium hypochlorite; sodium dihydrogenphosphate / butan-1-ol; water / 10 h

5: sodium hydroxide / 5 h / Reflux

With sodium hypochlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; In cyclohexane; water; acetonitrile; butan-1-ol; 1: |Suzuki Coupling;

DOI:10.1016/j.bmc.2012.09.065

upstream raw materials:

C₂₃H₂₂ClFN₂O₄

2-Bromo-5-fluorobenzoic acid

methyl 2-bromo-5-fluorobenzoate