(3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid

Base Information

Chemical Name:(3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid
CAS No.:1202575-69-6
Molecular Formula:C₂₁H₂₁F₃O₄
Molecular Weight:394.391
Hs Code.:

Synonyms:(3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid

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Chemical Property of (3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid

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Technology Process of (3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid

There total 5 articles about (3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1202577-88-5
Methyl (3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionate

: 1202575-69-6
(3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid

Guidance literature:: Methyl (3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 501334-19-6
methyl 3-[4-(tert-butyldimethylsilyloxybenzyl)phenyl]-3-oxopropanoate

: 1202575-69-6
(3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; formic acid / Noyori's catalyst / 0 - 35 °C / Inert atmosphere

2: silver(l) oxide / toluene / 20 - 110 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

5: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With formic acid; tetrabutyl ammonium fluoride; water; triethylamine; triphenylphosphine; sodium hydroxide; silver(l) oxide; diethylazodicarboxylate; Noyori's catalyst; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 68755-42-0
4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one

: 1202575-69-6
(3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

3: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With sodium tetrahydroborate; water; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene;