(2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester

Base Information

Chemical Name:(2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester
CAS No.:187872-22-6
Molecular Formula:C₄₆H₅₂N₂O₆
Molecular Weight:728.929
Hs Code.:

(2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester

Synonyms:(2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester

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Chemical Property of (2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester

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Technology Process of (2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester

There total 1 articles about (2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 187872-69-1
(2S,3S)-2-[5-Aminomethyl-3-(4-benzyloxy-benzyl)-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl]-3-methyl-pentanoic acid tert-butyl ester

: 187872-22-6
(2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; sodium carbonate; In 1,4-dioxane; for 20h;
DOI:10.1021/jm960553d

Reference yield:

: 187872-22-6
(2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester

: 187872-26-0
(2S,3S)-2-{(S)-3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid

: 187872-79-3
(2S,3S)-2-{(R)-3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 14h; Yield given. Yields of byproduct given;
DOI:10.1021/jm960553d

Reference yield:

: 187872-22-6
(2S,3S)-2-{3-(4-Benzyloxy-benzyl)-5-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-2-oxo-2,3,6,7-tetrahydro-azepin-1-yl}-3-methyl-pentanoic acid tert-butyl ester

: C₅₀H₆₈N₁₂O₁₁

Guidance literature:: Multi-step reaction with 3 steps

1: TFA, anisole / CH₂Cl₂ / 14 h / 0 °C

3: TFMSA, TFA, DMS, m-cresol / 0.25 h / 0 °C

With 2,3-dimercapto-succinic acid; trifluorormethanesulfonic acid; 3-methyl-phenol; methoxybenzene; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm960553d